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ThatТs right, your DNA. Researchers predict that the medicines of the future may not only look and work differently than those you take today, but tomorrowТs medicines will be tailored to your genes. In 10 to 20 years, many scientists expect that geneticsЧthe study of how genes influence actions, appearance, and healthЧwill pervade medical treatment. Today, doctors usually give you an УaverageФ dose of a medicine based on your body size and age. In contrast, future medicines may match the chemical needs of your body
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Knowing your unique genetic make-up could help your doctor prescribe the right medicine in the right amount, to boost its effectiveness and minimize possible side effects. Along with these so-called pharmacogenetic approaches, many other research directions will help guide the prescribing of medicines.
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The science of pharmacologyЧunderstanding the basics of how our bodies react to medicines and how medicines affect our bodiesЧis already a vital part of 21st-century research. Chapter 1, УABCs of Pharmacology,Ф tracks a medicineТs journey through the body and describes different avenues of pharmacology research today.
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Much of the most promising pharmacological research going on at universities across the country is sponsored by the National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health (NIH), U.S. Department of Health and Human Services.Working at the crossroads of chemistry, genetics, cell biology, physiology, and engineering, pharmacologists are fighting disease in the laboratory and at the bedside.
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The team observed that both grapefruit juice and sour orange juice increased blood levels of Plendil, as if the people had received a higher dose. Regular orange juice had no effect. Watkins and his coworkers have found that a chemical common to grapefruit and sour oranges, dihydroxybergamottin, is likely the molecular culprit. Another similar molecule in these fruits, bergamottin, also contributes to the effect. now why some peopleТs stomachs burn after they swallow an aspirin tablet?
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Or why a swig of grapefruit juice with breakfast can raise blood levels of some medicines in certain people? Understanding some of the basics of the science of pharmacology will help answer these questions, and many more, about your body and the medicines you take.
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Despite the fieldТs long, rich history and importance to human health, few people know much about this biomedical science. One pharmacologist joked that when she was asked what she did for a living, her reply prompted an unexpected question: УIsnТt Сfarm ecologyТ the study of how livestock impact the environment
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Of course, this booklet isnТt about livestock or agriculture. Rather, itТs about a field of science that studies how the body reacts to medicines and how medicines affect the body. Pharmacology is often confused with pharmacy, a separate discipline in the health sciences that deals with preparing and dispensing medicines.
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For thousands of years, people have looked in nature to find chemicals to treat their symptoms. Ancient healers had little understanding of how various elixirs worked their magic, but we know much more today. Some pharmacologists study how our bodies work, while others study the chemical properties of medicines.
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Once a drug gets absorbed, the next stage is distribution.Most often, the bloodstream carries medicines throughout the body. During this step, side effects can occur when a drug has an effect in an organ other than the target organ. For a pain reliever, the target organ might be a sore muscle in the leg; irritation of the stomach could be a side effect.Many factors influence distribution, such as the presence of protein and fat molecules in the blood that can put drug molecules out of commission by grabbing onto them.
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How you respond to a drug may be quite different from how your neighbor does. Why is that? Despite the fact that you might be about the same age and size, you probably eat different foods, get different amounts of exercise, and have different medical histories. But your genes, which are different from those of anyone else in the world, are really what make you unique. In part, your genes give you many obvious things, such as your looks, your mannerisms, and other characteristics that make you who you are. Your genes can also affect how you respond to the medicines you take. Your genetic code instructs your body how to make hundreds of thousands of different molecules called proteins.
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